Neuro-ophthalmology
Neuro-ophthalmology is a subspecialty that merges the fields of neurology and ophthalmology , often dealing with complex systemic diseases that have manifestations in the visual system .
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It focuses on diseases of the nervous system that affect vision, control of eye movements, or pupillary reflexes.
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Neuro-ophthalmology focuses on diseases of the nervous system that affect vision, control of eye movements , or pupillary reflexes .
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Neuro-ophthalmologists complete a residency in neurology or ophthalmology followed by a fellowship.
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Neuro-ophthalmologists initially complete a residency in either neurology or ophthalmology, then undertake a fellowship in Neuroophthalmology.
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The field deals with both afferent and efferent visual system disorders.
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Pathology referred to a neuro-ophthalmologist includes afferent visual system disorders (e.g. optic neuritis , optic neuropathy , papilledema , brain tumors or strokes ) and efferent visual system disorders
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Visual disturbances are a primary feature of diseases studied in this field.
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Study of diseases causing visual disturbances
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Efferent visual system disorders can include anisocoria, diplopia, ophthalmoplegia, ptosis, nystagmus, blepharospasm, seizures of the eye or eye muscles, and hemifacial spasm.
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efferent visual system disorders (e.g. anisocoria , diplopia , ophthalmoplegia , ptosis , nystagmus , blepharospasm , seizures of the eye or eye muscles, and hemifacial spasm )
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Improved functional neuroimaging is aiding in the assessment and management of conditions.
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Improved functional neuroimaging is paving the way for better understanding, assessment, and management of many neurologic and neuro-ophthalmologic conditions.
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The field is mostly non-procedural, but may involve eye muscle surgery for adult strabismus.
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neuro-ophthalmologists may be trained to perform eye muscle surgery to treat adult strabismus
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Optic nerve fenestration is performed for idiopathic intracranial hypertension.
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optic nerve fenestration for idiopathic intracranial hypertension
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Botulinum injections are used for blepharospasm or hemifacial spasm.
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botulinum injections for blepharospasm or hemifacial spasm
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Gene therapy is being explored in clinical trials for Leber hereditary optic neuropathy.
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clinical trials began in February 2014 to use gene therapy to treat Leber hereditary optic neuropathy
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Diagnostic studies can be normal even in patients with significant neuro-ophthalmic disease.
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diagnostic studies can be normal in patients with significant neuro-ophthalmic disease
Neuro-ophthalmology is a subspecialty that merges the fields of neurology and ophthalmology, often dealing with complex systemic diseases that have manifestations in the visual system. Neuro-ophthalmologists initially complete a residency in either neurology or ophthalmology, then undertake a fellowship in Neuroophthalmology. Since diagnostic studies can be normal in patients with significant neuro-ophthalmic disease,[1] a detailed medical history and physical exam is essential.
Pathology referred to a neuro-ophthalmologist includes afferent visual system disorders (e.g. optic neuritis, optic neuropathy, papilledema, brain tumors or strokes) and efferent visual system disorders (e.g. anisocoria, diplopia, ophthalmoplegia, ptosis, nystagmus, blepharospasm, seizures of the eye or eye muscles, and hemifacial spasm). The largest international society of neuro-ophthalmologists is the North American Neuro-Ophthalmological Society (NANOS),[2] which organizes an annual meeting and publishes the Journal of Neuro-Ophthalmology. Neuro-ophthalmologists are often faculty at large university-based medical centers. Patients often have co-existing diseases in other fields (rheumatology, endocrinology, oncology, cardiology).
Description
Neuro-ophthalmology focuses on diseases of the nervous system that affect vision, control of eye movements, or pupillary reflexes. Neuro-ophthalmologists often see patients with complex multi-system disease and unusual diagnosis. Neuro-ophthalmologists are often active teachers in their academic institution, and the first four winners of the prestigious Straatsma American Academy of Ophthalmology teaching awards were neuro-ophthalmologists.[3] Neuro-ophthalmology is mostly non-procedural, however, neuro-ophthalmologists may be trained to perform eye muscle surgery to treat adult strabismus, optic nerve fenestration for idiopathic intracranial hypertension, and botulinum injections for blepharospasm or hemifacial spasm.[4]
At the turn of the 20th century, there was no textbook in the English language on neuro-ophthalmology. In 1906, Dr. William Campbell Posey, Professor of Ophthalmology in the Philadelphia Polyclinic and Dr. William G. Spiller, Professor of Neurology in the University of Pennsylvania, edited The Eye and Nervous System: Their Diagnostic Relations By Various Authors J.B. Lippincott & Co. According to the Preface to this book, "Although it is generally conceded that a knowledge of neurology is indispensable to the ophthalmologist and that an acquaintanceship with ophthalmology is of the greatest service to the neurologist, there is no book in the English language which covers the ground where the two specialties meet."[5]
Frank B. Walsh was a pioneer of neuro-ophthalmology, helping to popularize and develop the field. Walsh was born in Oxbow, Saskatchewan in 1895 and earned a degree from University of Manitoba in 1921. He joined the Wilmer Ophthalmological Institute at Johns Hopkins University and began organizing Saturday morning neuro-ophthalmology conferences. Walsh compiled the first neuro-ophthalmology textbook, which was published in 1947 and has been updated over the years by generations of his students.[6]
Improved functional neuroimaging is paving the way for better understanding, assessment, and management of many neurologic and neuro-ophthalmologic conditions. As our understanding of neuroscience evolves, neuro-ophthalmologists are becoming increasingly better at treatment, rather than only diagnosis, and novel therapies are emerging to treat traditionally vision-devastating disease.[7] For example, clinical trials began in February 2014 to use gene therapy to treat Leber hereditary optic neuropathy,[8] which is one of the first uses of gene therapy in the central nervous system. Progress has also been made in understanding retinal ganglion cell regeneration and in re-establishing synaptic connections from the optic nerve to the brain,[1] more than in other regions of the central nervous system.[9][10] One of the goals of the National Institutes of Health is to use the visual system as a window to understand neural plasticity and regenerative medicine in the central nervous system,[11] an area of neuroscience that has a promising future and is intimately intertwined with neuro-ophthalmology.
- 1 2 Lessell, S (Apr 2000). "What can we expect in neuro-ophthalmology in the next century?". Archives of Ophthalmology. 118 (4): 553–4. doi:10.1001/archopht.118.4.553. PMID 10766142.
- ↑ "North American Neuro-Ophthalmology Society". North American Neuro-Ophthalmology Society Home Page. Archived from the original on 26 September 2014. Retrieved 28 September 2014.
- ↑ Frohman, LP (Sep 2008). "The human resource crisis in neuro-ophthalmology". Journal of Neuro-Ophthalmology. 28 (3): 231–4. doi:10.1097/wno.0b013e318185e084. PMID 18769291.
- ↑ Spitze, A; Al-Zubidi, N; Lam, P; Yalamanchili, S; Lee, AG (October 2014). "Neuro-ophthalmology as a career". Indian Journal of Ophthalmology. 62 (10): 1013–4. doi:10.4103/0301-4738.146007. PMC 4278112. PMID 25449937.
- ↑ Posey, William Campbell; Spiller, William G. (1906). The Eye and Nervous System: Their Diagnostic Relations by Various Authors. Philadelphia and London: J.B. Lippincott Company.
- ↑ Angelucci, Diane. "Groundbreaking neuro-ophthalmologist honored". EyeWorld. Archived from the original on 5 March 2015. Retrieved 28 September 2014.
- ↑ Newman, SA (Jun 2012). "Interventional neuro-ophthalmology: not an oxymoron". Journal of Neuro-Ophthalmology. 32 (2): 177–84. doi:10.1097/wno.0b013e318256638e. PMID 22617746. S2CID 35672897.
- ↑ Lam, BL; Feuer, WJ; Schiffman, JC; Porciatti, V; Vandenbroucke, R; Rosa, PR; Gregori, G; Guy, J (Apr 1, 2014). "Trial end points and natural history in patients with G11778A Leber hereditary optic neuropathy : preparation for gene therapy clinical trial". JAMA Ophthalmology. 132 (4): 428–36. doi:10.1001/jamaophthalmol.2013.7971. PMC 4266137. PMID 24525545.
- ↑ Watanabe, M; Fukuda, Y (Nov 2002). "Survival and axonal regeneration of retinal ganglion cells in adult cats". Progress in Retinal and Eye Research. 21 (6): 529–53. doi:10.1016/s1350-9462(02)00037-x. PMID 12433376. S2CID 46211858.
- ↑ Xia, Y; Nawy, S; Carroll, RC (Nov 7, 2007). "Activity-dependent synaptic plasticity in retinal ganglion cells". The Journal of Neuroscience. 27 (45): 12221–9. doi:10.1523/jneurosci.2086-07.2007. PMC 3073613. PMID 17989288.
- ↑ "NEI Audacious Goal Initiative". National Eye Institute. Retrieved 28 September 2014.