List of systemic diseases with ocular manifestations
An ocular manifestation of a systemic disease is an eye condition that directly or indirectly results from a disease process in another part of the body.
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Diabetes is the leading cause of new cases of blindness in those aged 20–74.
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Diabetes , for example, is the leading cause of new cases of blindness in those aged 20–74
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Diabetic retinopathy and macular edema affect up to 80% of patients who have had diabetes for 15 years or more.
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ocular manifestations such as diabetic retinopathy and macular edema affecting up to 80% of those who have had the disease for 15 years or more
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AIDS and hypertension commonly have associated ocular symptoms.
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Other diseases such as acquired immunodeficiency syndrome (AIDS) and hypertension are commonly found to have associated ocular symptoms.
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Many diseases are known to cause ocular or visual changes.
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There are many diseases known to cause ocular or visual changes.
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50-60% of patients with granulomatosis with polyangiitis have ophthalmologic manifestations.
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50-60% have ophthalmologic manifestations, which can be a presenting feature in a minority of patients.
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Granulomatosis with polyangiitis may cause proptosis, restrictive ophthalmopathy, and chronic orbital pain.
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may result in proptosis , restrictive ophthalmopathy , chronic orbital pain
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Chronic cases of granulomatosis with polyangiitis may involve orbital retraction syndrome and intractable socket pain.
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in chronic cases, orbital retraction syndrome and intractable socket pain
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Granulomatosis with polyangiitis may cause inflammation of the optic nerve, ophthalmoplegia, conjunctivitis, keratitis, scleritis, episcleritis, dacrocystitis, nasolacrimal duct obstruction, dacroadenitis, uveitis, and retinal vasculitis.
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Granulomatosis with polyangiitis may also cause inflammation of the optic nerve , ophthalmoplegia , conjunctivitis , keratitis , scleritis , episcleritis , dacrocystitis , nasolacrimnal duct obstruction, dacroadenitis , uveitis , and retinal vasculitis.
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Ophthalmologic manifestations can be a presenting feature of granulomatosis with polyangiitis in a minority of patients.
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which can be a presenting feature in a minority of patients.
An ocular manifestation of a systemic disease is an eye condition that directly or indirectly results from a disease process in another part of the body. There are many diseases known to cause ocular or visual changes. Diabetes, for example, is the leading cause of new cases of blindness in those aged 20–74, with ocular manifestations such as diabetic retinopathy and macular edema affecting up to 80% of those who have had the disease for 15 years or more. Other diseases such as acquired immunodeficiency syndrome (AIDS) and hypertension are commonly found to have associated ocular symptoms.[citation needed]
- Acne rosacea
- Albinism
- Atopic dermatitis
- Behçet's disease
- Cicatricial pemphigoid
- Ehlers–Danlos syndrome
- Epidermolysis bullosa
- Erythema multiforme
- Goltz–Gorlin syndrome
- Ichthyosis
- Incontinentia pigmenti
- Nevus of Ota
- Pemphigus
- Pseudoxanthoma elasticum
- Psoriasis
- Stevens–Johnson syndrome (Erythema multiforme major)
- Vogt–Koyanagi–Harada syndrome
- Xeroderma pigmentosum
- Angiomatosis retinae (Von Hippel–Lindau disease) (retinocerebellar capillary hemangiomatosis)
- Ataxia telangiectasia (Louis–Bar syndrome)
- Encephalotrigeminal angiomatosis (Sturge–Weber syndrome) (encephalofacial cavernous hemangiomatosis)
- Neurofibromatosis (von Recklinghausen's disease)
- Tuberous sclerosis (Bourneville's syndrome)
- Wyburn–Mason syndrome (racemose hemangiomatosis)
- Ankylosing spondylitis
- Dermatomyositis
- Periarteritis nodosa
- Reactive arthritis
- Rheumatoid arthritis
- Ehlers-Danlos Syndrome
- Sarcoidosis
- Scleroderma
- Systemic lupus erythematosus
- Temporal arteritis
- Relapsing polychondritis
- Granulomatosis with polyangiitis 50-60% have ophthalmologic manifestations, which can be a presenting feature in a minority of patients. Orbital disease is the most common manifestation, and may result in proptosis, , chronic orbital pain, and in chronic cases, orbital retraction syndrome and intractable socket pain. Granulomatosis with polyangiitis may also cause inflammation of the optic nerve, ophthalmoplegia, conjunctivitis, keratitis, scleritis, episcleritis, dacrocystitis, nasolacrimnal duct obstruction, , uveitis, and retinal vasculitis.
- Varicella (chickenpox)
- Rubeola (measles)
- Rubella (German measles)
- Variola (smallpox)
- Vaccinia
- Herpes simplex
- Herpes zoster
- Mumps
- Infectious mononucleosis
- Influenza
- Cytomegalic inclusion disease
- Pharyngoconjunctival fever ()
- Epidemic keratoconjunctivitis ()
- Human immunodeficiency virus (acquired immunodeficiency syndrome)
- Ebola[1]
- Rift Valley Fever[2]
- Dengue[3]
- Hantavirus[4]
- ↑ Bwaka, Mpia A.; Bonnet, Marie-José; Calain, Philippe; Colebunders, Robert; De Roo, Ann; Guimard, Yves; Katwiki, Kasongo R.; Kibadi, Kapay; Kipasa, Mungala A. (1999-02-01). "Ebola Hemorrhagic Fever in Kikwit, Democratic Republic of the Congo: Clinical Observations in 103 Patients". The Journal of Infectious Diseases. 179 (Supplement_1): S1–S7. doi:10.1086/514308. ISSN 0022-1899. PMID 9988155.
- ↑ Ikegami, Tetsuro; Makino, Shinji (2011-05-06). "The Pathogenesis of Rift Valley Fever". Viruses. 3 (5): 493–519. doi:10.3390/v3050493. PMC 3111045. PMID 21666766.
- ↑ "Dengue Eye Disease". The BMJ. 2017-07-06.
- ↑ Mehta, Salil; Jiandani, Prakash (September 2007). "Ocular features of hantavirus infection". Indian Journal of Ophthalmology. 55 (5): 378–380. doi:10.4103/0301-4738.33827. ISSN 0301-4738. PMC 2636028. PMID 17699950.
- Gonorrhea (ophthalmia neonatorum)
- Brucellosis
- Diphtheria
- Lyme disease
- Sepsis (bacterial metastatic endophthalmitis)
- Tularemia
- Leprosy (Hansen's disease)
- Tuberculosis
- Syphilis
- Lymphogranuloma venereum (chlamydial)
- Inclusion conjunctivitis (chlamydial)
- Malaria
- Toxoplasmosis
- Cri-du chat syndrome
- Schmid–Fraccaro syndrome
- Turner's syndrome
- Trisomy 13 (Patau's syndrome, )
- Trisomy 18 (Edwards' syndrome, )
- Trisomy 21 (Down syndrome)
- Deletion of long arm of chromosome 18
- Deletion of chromosome 18
- Ciliopathic genetic syndromes—A number of widely variant genetic disorders with occular phenotypes have been identified with genotypical ciliopathy.
- Arteriosclerosis
- Hypertension
- Pre-eclampsia (toxemia of pregnancy)
- Occlusive vascular disease (sudden)
- Occlusive vascular disease (slow, progressive)
- Thrombosis
- Use of hormonal contraception
- Endocarditis
- Myxoma
- Aortic arch syndrome (takayasu)
- Pre-eclampsia (toxemia of pregnancy)
- Thromboangiitis obliterans
- Hereditary telangiectasia (Rendu–Osler–Weber syndrome)
- Albinism
- Alkaptonuria
- Amyloidosis
- Chediak–Higashi syndrome
- Cystinosis
- Fabry's disease
- Galactosemia
- Gaucher's disease
- Gout
- Hemochromatosis
- Histiocytosis
- Homocystinuria
- Lipidoses
- Marfan's syndrome
- Weill–Marchesani syndrome
- Mucopolysaccharidosis
- Niemann–Pick disease
- Osteogenesis imperfecta
- Wilson's disease
- Alport's syndrome
- Azotemia (acute and chronic pyelonephritis)
- Lowe's syndrome
- Medullary cystic disease
- Nephrotic syndrome (acute glomerulonephritis, diabetic kidney, system lupus erythematosus)
- Renal transplantation
- Wilms' tumor (nephroblastoma)
- Pavan-Langston, Deborah (1990). Manual of Ocular Diagnosis and Therapy. Little, Brown and Company.