Infiltrative ophthalmopathy
Infiltrative ophthalmopathy is a condition found in 5-10% of patients with Graves disease that resembles exophthalmos, except that blurry or double vision is acquired because of weakness in the ocular muscles of the eye.
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Found in 5-10% of patients with Graves disease
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Infiltrative ophthalmopathy is found in 5-10% of patients with Graves disease
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No known correlation with patient's thyroid levels
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there is no known correlation with the patient's thyroid levels
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Differs from exophthalmos associated with Graves disease, which disappears when thyrotoxicosis is corrected
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Exophthalmos associated with Grave's disease disappears when the thyrotoxicosis is corrected
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Current hypothesis is that it may be autoimmune in nature targeting retrobulbar tissue
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The current hypothesis is that infiltrative ophthalmopathy may be autoimmune in nature targeting retrobulbar tissue
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Smoking may have a causative effect
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Smoking may also have a causative effect
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Blurry or double vision due to weakness in ocular muscles
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the blurry or double vision is acquired because of weakness in the ocular muscles of the eye
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High dose glucocorticoids
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Treatments consist of high dose glucocorticoids and low dose radiotherapy
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Low dose radiotherapy
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Treatments consist of high dose glucocorticoids and low dose radiotherapy
Infiltrative ophthalmopathy at times may not be cured.
| Infiltrative ophthalmopathy | |
|---|---|
| Specialty | Ophthalmology |
Infiltrative ophthalmopathy is found in 5-10% of patients with Graves disease and resembles exophthalmos, except that the blurry or double vision is acquired because of weakness in the ocular muscles of the eye.[1][2] In addition, there is no known correlation with the patient's thyroid levels. Exophthalmos associated with Grave's disease disappears when the thyrotoxicosis is corrected. Infiltrative ophthalmopathy at times may not be cured. Treatments consist of high dose glucocorticoids and low dose radiotherapy.[3] The current hypothesis is that infiltrative ophthalmopathy may be autoimmune in nature targeting retrobulbar tissue. Smoking may also have a causative effect.[2]
- ↑ Munjal, Y. P. (2015). API Textbook of Medicine (Volume I & II). JP Medical Ltd. p. 596. ISBN 9789351524151. Retrieved 5 December 2017.
- 1 2 McDougall, I. Ross (2013). Thyroid Disease in Clinical Practice. Springer. p. 90. ISBN 9781489928818. Retrieved 5 December 2017.
- ↑ Panglossi, Harold V. (2006). Antioxidants: New Research. Nova Publishers. pp. 93–95. ISBN 9781594549991. Retrieved 5 December 2017.
- Mallika, Ps; Tan, AK; Aziz, S; Alwi, SAR Syed; Chong, MS; Vanitha, R; Intan, G (2009). "Thyroid Associated Ophthalmopathy – A Review". Malaysian Family Physician. 4 (1): 8–14. PMC 4170380. PMID 25606151.
- Fox, Robert A. (1967-08-01). "Infiltrative Ophthalmopathy and Primary Hypothyroidism". Annals of Internal Medicine. 67 (2): 377. doi:10.7326/0003-4819-67-2-377. ISSN 0003-4819.