Brown's syndrome
Brown syndrome is a rare form of strabismus characterized by limited elevation of the affected eye.
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Brown syndrome is caused by a malfunction of the superior oblique muscle, causing difficulty moving the eye up, particularly during adduction.
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Brown syndrome is caused by a malfunction of the superior oblique muscle , causing the eye to have difficulty moving up, particularly during adduction (when eye turns towards the nose).
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The disorder may be congenital or acquired.
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The disorder may be congenital (existing at or before birth), or acquired.
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Harold W. Brown first described the disorder in 1950 and initially named it the 'superior oblique tendon sheath syndrome'.
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Harold W. Brown first described the disorder in 1950 and initially named it the "superior oblique tendon sheath syndrome".
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Congenital Brown syndrome results from structural anomalies and fibrous adhesions around the trochlear area.
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Congenital (present at birth) Brown syndrome results from structural anomalies other than a short tendon sheath but other fibrous adhesions may be present around the trochlear area.
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Acquired cases arise from trauma, surgery, sinusitis, and inflammation of the superior oblique tendon sheath in rheumatoid arthritis.
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Acquired cases arise from trauma, surgery, sinusitis and inflammation of the superior oblique tendon sheath in rheumatoid arthritis .
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In Brown's original series, there was a 3:2 predominance of women to men, with nearly twice as many cases involving the right eye as the left, and 10% of cases showed bilaterality.
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In Brown's original series there was a 3:2 predominance of women to men and nearly twice as many cases involved the right eye as the left. 10% of cases showed bilaterality.
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Limited elevation in the eye when head is straight up.
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Limited elevation in the eye when head is straight up
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Eyes point out in a straight up gaze (divergence in up gaze).
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Eyes point out in a straight up gaze (divergence in up gaze)
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Widening of the eyelids in the affected eye on adduction.
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Widening of the eyelids in the affected eye on adduction
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Head tilts backwards as compensatory chin elevation to avoid double vision.
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Head tilts backwards (compensatory chin elevation to avoid double vision)
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Near normal elevation in abduction.
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Near normal elevation in abduction
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Brown syndrome is usually diagnosed by taking a detailed history and performing physical exams, including certain eye movements.
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Brown syndrome is usually diagnosed by taking a detailed history and performing physical exams, including certain eye movements.
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Treatment is not obligatory if binocular vision is present and head position is correct.
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If binocular vision is present and head position is correct, treatment is not obligatory.
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Treatment is required for visual symptoms, strabismus, or incorrect head position.
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Treatment is required for: visual symptoms, strabismus, or incorrect head position.
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Acquired cases with active inflammation of the superior oblique tendon may benefit from local corticosteroid injections in the region of the trochlea.
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Acquired cases that have active inflammation of the superior oblique tendon may benefit from local corticosteroid injections in the region of the trochlea.
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The goal of surgery is to restore free ocular rotations.
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The goal of surgery is to restore free ocular rotations.
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Sheathotomy, advocated by Harold Brown, involves stripping the superior oblique tendon, but results are frequently unsatisfactory due to scar tissue reformation.
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The results of such a procedure are frequently unsatisfactory because of reformation of scar tissue.
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Tenotomy of the superior oblique tendon has the disadvantage of frequently producing superior oblique paresis.
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This has the disadvantage that it frequently produces a superior oblique paresis .
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Weakening of the inferior oblique muscle of the affected eye may be needed to compensate for iatrogenic fourth nerve palsy.
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Weakening of the inferior oblique muscle of the affected eye may be needed to compensate for iatrogenic fourth nerve palsy.
Surgical results are frequently unsatisfactory due to reformation of scar tissue, and tenotomy may produce superior oblique paresis.
| Brown syndrome | |
|---|---|
| Specialty | Ophthalmology |
Brown syndrome is a rare form of strabismus characterized by limited elevation of the affected eye. The disorder may be congenital (existing at or before birth), or acquired. Brown syndrome is caused by a malfunction of the superior oblique muscle, causing the eye to have difficulty moving up, particularly during adduction (when eye turns towards the nose). Harold W. Brown first described the disorder in 1950 and initially named it the "superior oblique tendon sheath syndrome".[1]
Harold W. Brown characterized the syndrome in many ways such as:[2]
- Limited elevation in the eye when head is straight up
- Eyes point out in a straight up gaze (divergence in up gaze)
- Widening of the eyelids in the affected eye on adduction
- Head tilts backwards (compensatory chin elevation to avoid double vision)
- Near normal elevation in abduction
Brown syndrome can be divided in two categories based on the restriction of movement on the eye itself and how it affects the eye excluding the movement:[3]
- Congenital (present at birth) Brown syndrome results from structural anomalies other than a short tendon sheath but other fibrous adhesions may be present around the trochlear area.
- Acquired cases arise from trauma, surgery, sinusitis and inflammation of the superior oblique tendon sheath in rheumatoid arthritis. Orbital floor fractures may trap the orbital tissue in such a way as to simulate Brown syndrome. Intermittent forms of vertical retraction syndrome have been associated with click, which occurs as the restriction is released (superior oblique click syndrome).
Brown syndrome is usually diagnosed by taking a detailed history and performing physical exams, including certain eye movements.[4]
If binocular vision is present and head position is correct, treatment is not obligatory. Treatment is required for: visual symptoms, strabismus, or incorrect head position.[3]
Acquired cases that have active inflammation of the superior oblique tendon may benefit from local corticosteroid injections in the region of the trochlea.[citation needed]
The goal of surgery is to restore free ocular rotations. Various surgical techniques have been used:[1][3]
- Harold Brown advocated that the superior oblique tendon be stripped. A procedure named sheathotomy. The results of such a procedure are frequently unsatisfactory because of reformation of scar tissue.
- Tenotomy of the superior oblique tendon (with or without a tendon spacer) has also been advocated. This has the disadvantage that it frequently produces a superior oblique paresis.
- Weakening of the inferior oblique muscle of the affected eye may be needed to compensate for iatrogenic fourth nerve palsy.
In Brown's original series there was a 3:2 predominance of women to men and nearly twice as many cases involved the right eye as the left. 10% of cases showed bilaterality. Familial occurrence of Brown syndrome has been reported.[3]
- 1 2 Emmett T. Cunningham; Paul Riordan-Eva (17 May 2011). Vaughan & Asbury's general ophthalmology (18th ed.). McGraw-Hill Medical. p. 246. ISBN 978-0071634205.
- ↑ Wright, KW (1999). "Brown's syndrome: diagnosis and management". Transactions of the American Ophthalmological Society. 97: 1023–109. PMC 1298285. PMID 10703149.
- 1 2 3 4 Myron Yanoff; Jay S. Duker (2009). Ophthalmology (3rd ed.). Mosby Elsevier. pp. 1359–1360. ISBN 9780323043328.
- ↑ Fu, Lanxing; Gurnani, Bharat; Malik, Jahanzeb (2025), "Brown Syndrome", StatPearls, Treasure Island (FL): StatPearls Publishing, PMID 33085357, retrieved 2025-08-27